Archive for September, 2011

charlie sheen celeb roast as seen on tv


The new Charlie Sheen roast enjoyed Search
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Online gamers crack AIDS enzyme puzzle
By AFP | Plugged In – Mon, Sep 19, 2011 12:19 PM EDT
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Online gamers have achieved a feat beyond the realm of Second Life or Dungeons and Dragons: they have deciphered the structure of an enzyme of an AIDS-like virus that had thwarted scientists for a decade.

Photo by AFP
The exploit is published on Sunday in the journal Nature Structural & Molecular Biology, where — exceptionally in scientific publishing — both gamers and researchers are honoured as co-authors.
Their target was a monomeric protease enzyme, a cutting agent in the complex molecular tailoring of retroviruses, a family that includes HIV.
Figuring out the structure of proteins is vital for understanding the causes of many diseases and developing drugs to block them.
But a microscope gives only a flat image of what to the outsider looks like a plate of one-dimensional scrunched-up spaghetti. Pharmacologists, though, need a 3-D picture that “unfolds” the molecule and rotates it in order to reveal potential targets for drugs.
This is where Foldit comes in.
Developed in 2008 by the University of Washington, it is a fun-for-purpose video game in which gamers, divided into competing groups, compete to unfold chains of amino acids — the building blocks of proteins — using a set of online tools.
To the astonishment of the scientists, the gamers produced an accurate model of the enzyme in just three weeks.
Cracking the enzyme “provides new insights for the design of antiretroviral drugs,” says the study, referring to the lifeline medication against the human immunodeficiency virus (HIV).
It is believed to be the first time that gamers have resolved a long-standing scientific problem.
“We wanted to see if human intuition could succeed where automated methods had failed,” Firas Khatib of the university’s biochemistry lab said in a press release. “The ingenuity of game players is a formidable force that, if properly directed, can be used to solve a wide range of scientific problems.”
One of Foldit’s creators, Seth Cooper, explained why gamers had succeeded where computers had failed.
“People have spatial reasoning skills, something computers are not yet good at,” he said.
“Games provide a framework for bringing together the strengths of computers and humans. The results in this week’s paper show that gaming, science and computation can be combined to make advances that were not possible before.”

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UBS 2 billion dollar loss party


One would think a 2 billion dollar loss is a clear indication of the fox in the hen-house.  Apparently no worries 17 banks have 191 billion dollars worth of US government lawsuits to contend with.  US debt is in the trillions, Grease, Spain, Italy, the euro in general is caput. Lets Party

New massage machine put out by Trojan.


After a neck operation rehab is slow, long, and boring.  To liven it up a little bit the new massage machine by Trojan  will arrive soon. The claim to the machine’s fame is that it rotates creating a  wonderful experience. Hoping it works on my repaired neck I’m sitting here waiting for the delivery of the masterful machine.  The commercial showed everyone with a good neck.

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